Cordyceps Anti-Fatigue Studies

The Effect of Cordyceps sinensis on Fatigue in Healthy Adults: A Systematic Review and Meta-Analysis” looked at the effects of Cordyceps on fatigue in healthy adults. The study included nine eligible studies, which included a total of 552 participants. The study concluded that Cordyceps sinensis had a beneficial effect on fatigue in healthy adults, with an overall effect size of 0.55.

I didn’t know what effect size in statistics actually means and had to look it up. In short, there are two standard ways of stating how effectual a study is , either by usine Cohen’s d or Pearson’s r. With Cohen’s d, the effect size is considered medium and using Pearson’s r it is seen as great. I assume Pearson’s r was uses as it explains the strength of relationships between variables.
So, the effect on reducing fatigue using Cordyceps mushrooms is great.
The study mentioned that the active compounds in Cordyceps are cordycepin, cordycepic acid also known as D-Mannitol (, and polysaccharides, which are believed to be responsible for its anti-fatigue effects. Cordycepin and cordycepic acid are believed to act as stimulants and have antioxidant properties, while polysaccharides are believed to have immunomodulatory and anti-fatigue effects.

What is Cordycepic Acid?

Cordyceps mushrooms have been the subject of numerous studies exploring their potential benefits for athletic performance and lung function. One study published in the “Journal of Alternative and Complementary Medicine” found that supplementing with cordyceps improved endurance exercise performance in healthy older adults.

Another study published in the “Journal of International Society of Sports Nutrition” found that supplementing with cordyceps extract led to significant improvement in lung function and exercise performance in healthy athletes.

The active ingredient in cordyceps mushrooms that is believed to be responsible for these benefits is cordycepic acid. This compound has been shown to have antioxidant, anti-inflammatory, and immune-boosting properties, which may help to improve athletic performance and lung function.

Overall, the research suggests that cordyceps mushrooms and their active ingredient cordycepic acid have potential benefits for athletic performance and lung function.

What is Cordycepin?

Cordycepin is a compound found in cordyceps mushrooms and is believed to have a range of potential health benefits. It’s a type of nucleoside analogue, meaning it has a structure similar to the building blocks of DNA and RNA, and it’s thought to have properties that may improve athletic performance, boost energy levels, and support lung function.

Studies have shown that cordycepin may have an impact on various aspects of physical performance, including endurance, strength, and stamina. Additionally, research has suggested that it may improve lung function by increasing the availability of oxygen to the body, making it a great choice for anyone looking to enhance their athletic performance or support their respiratory health.

So if you’re looking to reap the benefits of cordycepin, consider incorporating cordyceps mushrooms into your diet. Whether you’re a fitness enthusiast or just looking for a natural way to support your overall well-being, the potential benefits of this compound are certainly worth exploring!

Cordycepin and cordycepic acid are both compounds found in cordyceps mushrooms, a type of fungus that grows on insects in high-altitude regions. While they are similar in many ways, there are some key differences between the two compounds that are worth noting.

Cordycepin is a nucleoside analog and is known for its potent antiviral and anti-tumor properties. It is thought to work by inhibiting the replication of DNA and RNA in cells, which can slow down or stop the growth of viruses and cancer cells.

So how does Cordycepin reduce fatigue?

Cordycepin is a nucleoside compound that is believed to have anti-inflammatory properties, and some studies suggest that it may help reduce fatigue and improve energy levels. For example, a study published in the Journal of Pharmacy and Pharmaceutical Sciences found that cordycepin supplementation in mice resulted in reduced physical fatigue and improved exercise endurance.


Several studies have investigated the effects of cordyceps on fatigue, with some suggesting that it may have potential benefits for reducing feelings of fatigue and increasing physical endurance. However, it’s important to note that the evidence is limited and further research is needed to fully understand the effects of cordyceps on fatigue. Additionally, the quality of some of the studies is not high, and the effects of cordyceps on fatigue may vary depending on the individual. As a result, more high-quality studies are needed to better understand the potential benefits of cordyceps for reducing fatigue.

Thanks for reading,

B. Ebene

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